Royal Air Force Typhoon FGR4s have conducted a mission with French warplanes in a combined operation on an subterranean weapons facility in Syria used by the IS group, as stated by the UK's MoD.
The location, identified by surveillance, was thought to be housing weapons and explosive materials, the statement said, and was located in hills just north of the ancient city of Palmyra in the heart of Syria.
"Our fighter planes employed precision-guided Paveway IV munitions to strike a number of approach shafts providing entry to the depot... preliminary assessments suggest the objective was successfully hit," the MoD said.
There was no indication of any harm to civilians in the operation conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon fighters were supported by a Voyager tanker plane.
IS - referred to as ISIS - established extremist governance over significant areas in Syria and Iraq prior to its 2019 collapse.
"This strike underscores British leadership, and determination to operate in unison with allied nations, to stamp out any revival of IS and their dangerous and violent ideologies in the region," the British Defence Secretary John Healey remarked.
British military aircraft have performed surveillance missions over Syrian airspace to "deter any attempted resurgence" of Islamic State after its routing at the climactic battle in Baghuz in the year 2019, the authorities noted.
"I extend gratitude to all the members of British forces who took part in this mission for their skill and their valour," Healey said. "They were among thousands of UK service members on duty over the holidays. This operation, to eliminate terrorist threats who pose a risk to our security, demonstrates how British military are prepared to act, throughout the year, keeping Britain secure within its borders and powerful internationally."
Last December, the United States armed forces conducted what it termed a "massive strike" against IS targets in the country, after an attack resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The U.N. estimates Daesh still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.